The VIB-Center for Inflammation Research (Ghent, Belgium), headed by Prof. Bart Lambrecht, is a vibrant and international research center where outstanding questions related to inflammation and inflammatory diseases are tackled.
The laboratory for Mouse Genetics in Inflammation (Prof. Claude Libert) is studying the mechanism of host-pathogen interactions, in mice, within the context of infectious diseases, such as sepsis. Sepsis is a huge unmet medical need, usually resulting from polymicrobial infections. Recent studies suggest that 49 million people develop sepsis each year, leading to 11 million deaths, i.e. one on five deaths per year, globally.
This group is studying sepsis via two major projects, one is the impact of sepsis on metabolic pathways with a focus on liver, and the other is a study of microbes in the gut (the gut microbiome) and how these microbes are kept under control by local control mechanisms, mainly by Paneth cells. These cells control the composition of the gut microbiome in a largely unknown way, and microbes are also triggering inflammation and cell death of Paneth cells, trying to eliminate them. This continuous struggle can lead to escapes of bacteria from the gut to peripheral organs and to sepsis. The mechanisms at work in Paneth cells are quite unknown.
This project is uncovering the most important mechanisms, by purifications of Paneth cells, study of their transcriptomics regulation (by inflammation and by nutrition compounds) and mutagenesis of these cells.
A postdoc or PhD position is open with a focus on further study of Paneth cells in relation to gut homeostasis. The team uses advanced molecular and biochemical approaches (Transcriptomics, spatial Transcriptomics, FACS sorting, CRISPR/Cas9 gene editing) as well as superresolution microscopy and EM to functionally explore Paneth cell function in cellular and small animal models, including mice.
We seek a young and ambitious junior postdoc or PhD fellow with a biochemical and/or cell biological background and proficient experience in molecular biology, FACS and trancriptomics analysis. The ability to work in a multidisciplinary research team as well as effective communication and writing skills and a good mastery of the English language are essential for a successful selection.
Financial support is available for the duration of 4 yrs, but the successful candidate is encouraged to obtain independent funding during this time. Starting date 1 october 2020.
How to apply?
Motivated candidates are asked to apply online. For more information, you can contact Claude Libert.
Applications must include a CV as well as (i) a letter of motivation explaining why you are interested in our work and aspire a postdoc; and (ii) the names of two contact people to provide recommendations (PhD thesis mentor must be included).
Profile and selected papers of the Libert lab can be found on: http://www.vib.be/en/research/...