Postdoc position: Microglia-synapse molecular interactions in neurodegenerative disorders

Antwerp VIB-UAntwerp Center for Molecular Neurology

10 Jan 2021

Antwerp

VIB-UAntwerp Center for Molecular Neurology

Joris de Wit Lab, Renzo Mancuso Lab

Post-doctoral

1

About the labs

The Mancuso lab (Microglia and Inflammation in Neurological Disorders, MIND) at the VIB-UAntwerp Center for Molecular Neurology and the De Wit lab (Laboratory of Synapse Biology) at the VIB-KU Leuven Center for Brain & Disease Research, Belgium, are seeking a highly motivated postdoctoral fellow to work on a project on microglia-synapse interactions in neurodegenerative disorders.

About the project

Microglia and neuroinflammation play a central role in the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. Microglia interactions with synapses are essential for neural circuit development and function, but the role and molecular mechanisms of microglia-synapse interactions in the pathogenesis of neurodegenerative disorders remain poorly understood. This project will use mouse models, multi-omics approaches, iPSC, and cutting-edge humanized mouse systems to unravel how microglia-synapse interactions contribute to the initiation and perpetuation of neurodegenerative disease.

Your job

This is a project at the interface of two labs: the Mancuso lab, working on human and mouse microglia biology in brain disorders, and the Laboratory of Synapse Biology working on the molecular mechanisms that control precise synaptic connectivity in healthy and diseased neural circuits (see references below). 

In this project, you will make use of innovative multi-omics approaches, genome engineering, viral vector technology, iPSC, and humanized mouse technology to unravel the role and molecular mechanisms of microglia-synapse interactions in neurodegenerative disorders. 

The successful applicant will work in both labs and divide the time between the two sites.

Selected references:

  • Mancuso et al. Nat Neurosci (2019). 22:2111-2116
  • Fattorelli, Martinez Muriana et al. Nat Protocols (2020), in press
  • Apóstolo et al. Nat Commun (2020). 11(1):5171
  • Rice et al. Science (2019). 363(6423)
  • Condomitti et al. Neuron (2018). 100:201-215

Profile

We are seeking a highly motivated, enthusiastic, critical, and creative individual to join our teams. The candidate should have a strong interest in neurobiology.

Essential

  • Ph.D. in neurobiology (molecular, cellular, developmental, systems) or related disciplines
  • A solid publication record with first-author research publication(s) in peer-reviewed international journals
  • Team player

Desirable but not required

  • Prior experience with mouse neurobiology and molecular biology
  • Prior experience with transcriptomics, proteomics, or bioinformatics
  • Prior experience with iPSC biology
  • Prior experience with microglia biology

We offer

  • A versatile and challenging job in a vibrant, world-class research environment operating at an international level
  • State of the art research facilities
  • A dedicated training program to broaden your expertise and enhance your skillset
  • A competitive compensation package based on expertise and experience
  • Financial support for at least 2 years. The successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO, or national funding organizations)

Starting Date: as soon as possible

How to apply?

For more information contact renzo.mancuso@uantwerpen.vib.be and joris.dewit@kuleuven.be. Please complete the online application procedure and include a motivation letter, a detailed CV incl. list of publications, and the contact information of three referees.