PhD position in computational biology to investigate the cellular phase of Alzheimer’s disease

Leuven VIB-KU Leuven Center for Brain & Disease Research

23 Feb 2021

Leuven

VIB-KU Leuven Center for Brain & Disease Research

Bart De Strooper Lab

PhD

1

PhD position in computational biology to investigate the cellular phase of Alzheimer’s disease using spatial transcriptomics

Description

The Laboratory for the Research of Neurodegenerative Diseases headed by prof. Bart De Strooper is a vibrant environment where key issues related to Alzheimer’s disease are tackled. We are currently looking for a highly motivated Ph.D. candidate to join our multidisciplinary project on the cellular response to Alzheimer’s pathology (De Strooper and Karran, Cell, 2016). 

In this project, we will investigate data generated using Spatial Transcriptomics of an Alzheimer’s Disease mouse model (Chen and Lu, Cell, 2020) and integrate with both in-house and 3rd party multi-omics data. The goal is to create a detailed understanding of spatial and transcriptional changes of all relevant cell types around amyloid-beta plaques in a mouse brain. Detailed understanding hereof will yield new and more detailed hypotheses on how to approach AD in human patients.

Profile

Required

  • Master's degree in computational biology, biomedicine, genetics or equivalent.
  • Background, or demonstrable interest, in computational biology and data analysis
  • Strong interest in brain pathology and Alzheimer’s Disease
  • Critical mindset and a fast learner
  • Ability to collaborate in a multidisciplinary project with international and national partners in academia, industry and the clinics
  • Good time management and communication skills
  • Good mastery of English language

Appreciated

  • Knowledge of spatial and/or single-cell omics applications
  • Experience with image analysis and/or statistics
  • Knowledge of the genetics of Alzheimer’s disease

We offer

  • A stimulating, diverse, international and exceptionally strong research environment in a world-class academic laboratory with a focus on Alzheimer’s disease
  • Opportunity to learn state of the art technology
  • Opportunity to work with an excellent bioinformatics team
  • Access to state-of-the-art infrastructure,
  • Financial support is available. However, the successful candidate is encouraged to obtain a personal fellowship.

Start date: as soon as possible - the position is available immediately

How to apply?

Please complete the online application procedure and include a detailed CV, a motivation letter describing research interests, previous research experience and a list of publications.

For more information: please contact mark.fiers@kuleuven.be