ERC funded Postdoc position to investigate the cellular phase of Alzheimer’s disease

Leuven VIB-KU Leuven Center for Brain & Disease Research

04 Sep 2021

Leuven

VIB-KU Leuven Center for Brain & Disease Research

Bart De Strooper Lab

Post-doctoral

1

08 Sep 2021

ERC funded Postdoc position to investigate the cellular phase of Alzheimer’s disease using spatial transcriptomics and proteomics

Description

The Laboratory for the Research of Neurodegenerative Diseases headed by prof. Bart De Strooper is a vibrant environment where key issues related to Alzheimer’s disease are tackled. Within the frame of an ERC Advanced grant, we are currently looking for a highly skilled and motivated postdoc to join our multidisciplinary project on the cellular response to Alzheimer’s pathology (De Strooper and Karran, Cell, 2016; Chen, Lu,…Fiers, De Strooper Cell, 2020). 

In this project we will investigate the expression of risk genes for Alzheimer’s Disease and how their expression changes in different cell types over the course of Alzheimer’s disease. Understanding how risk genes are expressed over the disease evolution will help us to identify new drug targets. The candidate will use spatial omics such as spatial transcriptomics, in situ sequencing, and multiplexed proteomics to untangle the cellular response to amyloid plaques and tangles in resilient and Alzheimer’s brains.

Profile

Required

  • PhD in biomedicine, genetics, bioengineering or equivalent
  • Strong background in molecular biology
  • Interested to work in the field of Alzheimer’s Disease
  • Critical mindset, fast learner & team player
  • Ability to collaboratively lead a multidisciplinary project with international and national partners in academia, industry and the clinics
  • Project management and effective communication skills
  • Good mastery of English language

Appreciated

  • Experience in image analysis
  • Strong background and hands-on experience with brain pathology
  • Familiarity with R or python
  • Solid scientific and operational knowledge of fit-for-purpose state-of-the-art omics platforms (transcriptomic, genetics, proteomics,…) at single cell resolution and the selection and application of appropriate data analysis methodologies, especially in the context of human translational studies
  • Knowledge on the genetics of Alzheimer’s disease

Offer

  • A stimulating, diverse, international and exceptionally strong research environment in a world-class academic laboratory with a focus on Alzheimer’s disease
  • Opportunity to learn state of the art technology
  • Opportunity to work with an excellent bioinformatics team
  • Access to state-of-the-art infrastructure
  • Financial support is available for at least 2 years. However, the successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO or National funding organizations).

Start date: as soon as possible - the position is available immediately

How to apply?

Please complete the online application procedure and include a detailed CV, contact information of at least 2 references, a motivation letter describing research interests and previous research experience and a list of publications.

For more information: please contact weiting.chen@kuleuven.be.