Postdoc in Alzheimer’s disease using cutting edge genomic approaches

Leuven VIB-KU Leuven Center for Brain & Disease Research

06 Nov 2021

Leuven

VIB-KU Leuven Center for Brain & Disease Research

Bart De Strooper Lab

Post-doctoral

1

Postdoc in Alzheimer’s disease using cutting edge genomic approaches in collaboration with a Biotech company start-up

Description

The Laboratory for the Research of Neurodegenerative Diseases headed by prof. Bart De Strooper is a vibrant environment where key issues related to Alzheimer’s disease are tackled. We are currently looking for a highly skilled and motivated postdoc to join our multidisciplinary project on the cellular response to Alzheimer’s pathology (De Strooper and Karran, Cell, 2016). 

We have used spatial transcriptomics (Chen and Lu, Cell, 2020) to investigate why some people remain protected against Alzheimer’s Disease despite the presence of amyloid plaques. Understanding resilience to Alzheimer’s disease will help us to identify new drug targets. We are looking for an expert postdoc to validate these targets using cutting edge Perturb-seq and other approaches. 

The success!ful candidate will closely collaborate on discovery biology, interpretation and identification of novel drug targets, together with the wider team of biologists and bioinformaticians. The successful candidate will be responsible for the target mining and validation. This project is funded by an industrial project in collaboration with a biotech start-up.

Profile

Required

  • PhD in biomedicine, genetics or equivalent
  • Strong background and hands-on experience with genome editing and Crisper/CAS9 technologies
  • Experience with cell culture and animal models
  • Strong interest in drug discovery and development
  • Strong interest to work in the field of Alzheimer’s Disease
  • Critical mindset, fast learner & team player
  • Ability to collaboratively lead a multidisciplinary project with international and national partners in academia, industry and the clinics
  • Project management and effective communication skills
  • Good mastery of English language

Appreciated

  • Experience with Perturb-seq or Crop-seq or similar technologies
  • Knowledge of the genetics of Alzheimer’s disease
  • Experience with image analysis and/or statistics
  • Experience with computational biology and data analysis
  • Knowledge of spatial or single cell omics applications

We offer

  • A stimulating, diverse, international and exceptionally strong research environment in a world-class academic laboratory with a focus on Alzheimer’s disease and the possibility to step into a spin-off company.
  • Opportunity to learn state of the art technology
  • Opportunity to work with an excellent bioinformatics team
  • Access to state-of-the-art infrastructure
  • Funding is available for at least one year with the possibility for extension

Start date: as soon as possible - the position is available immediately

How to apply?

Please complete the online application procedure and include a detailed CV, contact information of min. 2 references, a motivation letter describing research interests and previous research experience and a list of publications.

For more information: please contact weiting.chen@kuleuven.be.