Postdoc – Cotranslational protein folding and aggregation

Leuven VIB-KU Leuven Center for Brain & Disease Research

01 May 2022

Leuven

VIB-KU Leuven Center for Brain & Disease Research

Frederic Rousseau and Joost Schymkowitz Lab

Post-doctoral

1

About the lab

The SWITCH Laboratory is one of the leading laboratories in human disease-related protein aggregation. It is an interdisciplinary workplace, bringing together about twenty researchers from different backgrounds, such as bioinformatics, biophysics and cell biology. SWITCH has a unique platform of technologies for studying protein aggregation, including biophysical, ultrastructural and cell biological instrumentations.

For a primer on who we are, what we do and our latest publications, see http://www.switchlab.org/

Your Job

You will investigate the relation between cotranslational folding, the native protein structure, and its aggregation. You will use computational modelling techniques as well as experimental approaches, using purified proteins, cell-free translation assays, and in omics methods in cells. The goal is to identify the determinants of cotranslational protein aggregation and the role of aggregation gatekeepers therein.

Profile

  • Ph.D. in a topic related to protein aggregation
  • Strong interest in protein aggregation and its role in disease.
  • A solid publication record with first-author research publication(s) in peer-reviewed international journals
  • Expertise in biophysical or biochemical methods to study protein aggregation
  • Previous experience with optical tweezers or AFM is a plus
  • Previous experience with ribosome sequencing is a plus
  • Highly motivated, enthusiastic, critical and creative
  • The ability to work in a multidisciplinary team is a must
  • Prior experience with high content analysis is a plus

We offer

Starting Date: as soon as possible

How to apply?

For more information contact  hannah.wilkinson@kuleuven.be. Please complete the online application procedure and include a detailed CV including a list of publications, a motivation letter, and the contact information of three referees.

Interested in a virtual visit? Visit us at https://360.cbd.vib.be