We are the Computational Neurobiology lab and address fundamental questions in chromatin organization, epigenetics, and brain biology. We develop machine learning approaches for large-scale data integration and reconstruct cis-regulatory networks to understand how a cell “chooses” its fate. In particular, we focus on the role of chromatin organization in neuronal cell fate specification and neurodegenerative disease, aiming to bring the results of fundamental research to the clinic.
The project aims to understand the mechanisms underlying neuro-immune crosstalk in AD development and progression. To this end, the successful candidate will integrate large single-cell and bulk datasets across multiple data modalities into cis-regulatory networks, with a particular focus on chromatin organisation. The project will require both the application of state-of-the-art statistical and machine learning approaches and their further development to address the unique complexities of chromatin organisation data.
The VIB-UAntwerp Center for Molecular Neurology has 6 PIs and hosts internationally recognized leaders in the field of Neurogenetics and Neuroinflammation. Current research groups address a broad set of questions related to neurodegenerative diseases of the central and peripheral nervous system, with an emphasis on understanding the genetic etiology and developing diagnostics and treatment methods for these diseases. Approaches range from human genetics and genomics to protein biochemistry and neuronal and glial cell biology, while models include yeast, fly, mouse, and pluripotent human cell systems. Research groups have access to state-of-the-art research and top-notch support core facilities and attract talented international scientists from across the world.
The VIB-UAntwerp Center is part of VIB, a Life Sciences institute with colleague-researchers in cancer, biotechnology, structural biology, and immunology amongst others, and an extensive set of core facilities and opportunities for technology transfer. We are also embedded within the University of Antwerp.
The candidate should:
- have a Ph.D. in Computational Biology, Bioinformatics, Systems Biology, Mathematical biology, or related disciplines
- have excellent communication, organizational, and writing skills in English.
- be motivated and independent, while being able to interact effectively with other members of the team.
- Machine learning
- Single-cell data analysis
- Causal Inference
- Graph Theory
- Financial support for at least 2 years. The applicant will be assisted in applying for personal fellowships during this time (Marie-Curie, HFSP, EMBO, National funding organizations).
- Access to state-of-the-art infrastructure and core computing and experimental facilities in a vibrant, world-class research environment operating at an international level
- Dedicated training programs available through VIB and UAntwerp to broaden your expertise and enhance your skillset
- A stimulating and international research environment
- A strong and dynamic network of international collaborators
As part of the VIB-UAntwerp Center for Molecular Neurology and VIB, the applicant will benefit from established collaborations and access to centralized facilities with expertise in genomics, functional genomics and cell biology, proteomics, cutting-edge microscopy, structural biology, technology development, and bioinformatics.
VIB provides a highly interactive environment and ample training opportunities for its researchers. The VIB-UAntwerp Center for Molecular Neurology is located in the city of Antwerp, the capital of Flanders, offering a culturally and historically rich, and ethnically diverse environment.
Starting date: as soon as possible
How to apply?
You can apply for this job through the online job application platform. Don’t forget to include the following document(s):
- a detailed CV
- a letter of motivation describing your interests and contact details of two referees