The Jo Van Ginderachter lab is looking for an excellent postdoctoral scientist interested in understanding the mechanisms that regulate the heterogeneity and pro-tumoral activity of tumor-associated macrophages, and how we can use such mechanisms to optimize immunotherapy. In particular, we want to understand how lipids and altered lipid metabolism regulate tumor-associated macrophages and whether we can reprogram the macrophages by interfering with lipid metabolism.
This project is embedded in an ambitious, excellence-based research consortium on strategic basic research with an economic finality (FWO-SBO program LipoMacs) consisting of six Flemish partners (Jo Van Ginderachter-VIB/ Vrije Universiteit Brussel, Johan Swinnen-KULeuven, Massimiliano Mazzone- VIB/KULeuven, Jerome Hendriks-UHasselt, Charlotte Scott, VIB/UGent). The candidate will be an active part of this consortium and will interact and collaborate with the other partners.
The project relies on cutting-edge lipidomics, spatial lipidomics and spatial multiomics technologies to map the heterogeneity of macrophages at the level of lipid metabolism. This project is also further supported by a bioinformatician in the JVG lab.
The JVG lab is located at the Science/Humanities campus of the Vrije Universiteit Brussel, in the center of Brussels and in the heart of Europe, and is part of the excellence-based VIB Center for Inflammation Research (director: Bart Lambrecht).
Geeraerts X, Fernandez-Garcia J, …, Van den Bossche J*, Fendt SM*, Van Ginderachter JA*. *Equal contribution. Macrophages are metabolically heterogeneous within the tumor microenvironment. Cell Reports 2021, doi: 10.1016/j.celrep.2021.110171.
Pombo Antunes AR, Scheyltjens I, ...Van Ginderachter JA*, Movahedi K*. *Equal contribution. Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nature Neuroscience 2021, doi: 10.1038/s41593-020-00789-y
Van Damme H, …, Laoui D*, Van Ginderachter JA*. *Equal contribution. Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy. Journal for Immunotherapy of Cancer 2021, doi: 10.1136/jitc-2020-001749
Bieniasz-Krzywiec P, …, Van Ginderachter JA, Mazzone M. Podoplanin-expressing macrophages promote lymphangiogenesis and lymphoinvasion in breast cancer. Cell Metabolism 2019, doi: 10.1016/j.cmet.2019.07.015
Laoui D, Keirsse J, ..., Van Ginderachter JA. The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity. Nature Communications 2016. doi: 10.1038/ncomms13720
- Ph.D. in biology, bio-engineering sciences, medical sciences, biomedical sciences, or related disciplines
- Solid publication record
- Experienced in immunology, preferably myeloid cell biology and/or metabolism of immune cells
- Experienced in working with mouse models (FELASA B or C required)
- Experience with flow cytometry and lipidomics or other omics technologies is highly beneficial
- Experience in tumor immunology is beneficial
- Excellent spoken and written English skills
- Creative, highly motivated, independent, team player
- The possibility to independently lead your research project, but with sufficient guidance and mentoring
- Excellent training conditions, with the possibility to learn a wide set of cutting-edge technologies
- A friendly, dynamic, and scientifically stimulating working environment, with a team of highly motivated scientists
- Long-term career opportunities
- Funding for up to 4 years. However, you will be encouraged to also apply for personal fellowships
1 October 2022
How to apply?
- A detailed CV, containing a full list of publications
- Motivation letter
- Summary of past research
- Names and contact information of 2-3 referees
For additional information on the position contact Prof. Dr. Jo Van Ginderachter (firstname.lastname@example.org)